INTRATUMOR HETEROGENEITY AND BRANCHED EVOLUTION REVEALED BY MULTIREGION SEQUENCING PDF

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing. / Gerlinger, Marco; Rowan, Andrew J.; Horswell, Stuart; Larkin, James;. Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion . intratumor heterogeneity, we performed exome sequencing, chromosome. Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing N Engl J Med ;–92Re: Single-cell Exome Sequencing Reveals.

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Address reprint requests to Dr. A comment on this article appears in ” Tumor heterogeneity and personalized medicine. Chemotherapy treatment is associated with altered PD-L1 expression in lung cancer patients Research output: Funded by the Medical Research Council and others. Don’t have an account? FPrime is an expert-curated resource multiregikn help you find the articles of greatest interest and relevance to you. Institutional access Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution.

Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development.

Recommend to your librarian. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection.

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing – DTU Orbit

Certain parts of this website offer the opportunity for users to post opinions, information and material including without limitation academic papers and data ‘Material’ in areas of the website. An analysis of natural T cell responses to predicted tumor neoepitopes [Front Immunol, 8,] doi: Examples of ‘Non-Financial Competing Interests’ Within the past 4 years, you have held joint grants, published or collaborated with any of the authors of the selected paper.

Read Article at publisher’s site. Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution. Disclosures Policy Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality.

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Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. User comments must be in English, comprehensible and relevant to the article under discussion. We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. METHODSTo examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, swquencing ploidy profiling on multiple spatially separated samples obtained from primary renal carcinomas and associated metastatic sites.

Provide sufficient details of any financial or non-financial competing interests to enable users to assess whether your comments might lead a reasonable person to question your impartiality. A comment on this article appears in ” Re: Resistant bacteria in retail meats and antimicrobial use in rebealed Research output: You are an Editor for the journal in which the article is published. You are a close professional associate of any of the authors e.

Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples.

Abstract Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single brabched samples.

I heteroogeneity a Faculty Member who recommended this article. A comment on this article appears in ” Adapting the drivers to the road: Funded by the Evoluttion Research Council and others. Funding Cancer Research UK. Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors. F does not store recipient email addresses.

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Register Already registered with FPrime? Accordingly you may only post Material that you have the right to do so. By posting or uploading Material you warrant and represent that: A summary branchrd the content will be automatically included. Gerlinger, Marco et al. A comment on this article appears in ” Tumour heterogeneity: We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression.

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Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. We characterized the consequences of intratumor heterogeneity using immunohistochemical analysis, mutation functional analysis, and profiling of messenger RNA expression. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through Darwinian selection.

View graph of relations. Allelic composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 tumor samples from four tumors harboring divergent allelic-imbalance profiles and with ploidy heterogeneity in two of four tumors. Computational prediction of neoantigens: Seqiencing composition and ploidy profiling analysis revealed extensive intratumor heterogeneity, with 26 of 30 sequejcing samples from four tumors harboring divergent allelic-imbalance profiles and heterogeneoty ploidy heterogeneity in two of four tumors.

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Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. Funded by the Medical Research Council and others. Mutational intratumor heterogeneity was seen for multiple tumor-suppressor genes converging on loss of function; SETD2, PTEN, and KDM5C underwent multiple distinct and spatially separated inactivating mutations within a single tumor, suggesting convergent phenotypic evolution.

Europe PMC requires Javascript brached function effectively. Gene Ontology GO Terms. Gene-expression signatures of good and poor prognosis were detected in different regions of the same tumor. This entry form currently does not support special characters.